Deeply researched interviews
Showing all 143 episodes · Only those about AI
Adam Marblestone is CEO of Convergent Research. He’s had a very interesting past life: he was a research scientist at Google Deepmind on their neuroscience team and has worked on everything from brain-computer interfaces to quantum…
New episode with military historian Si Sheppard.
This is the final lecture in our series with Sarah Paine, and it's a fitting place to end.
New episode with Noam Brown.
New episode with John Schulman, Charlie O’Neill, and Beren Millidge.
Ajeya Cotra is a researcher at METR, where she works on threat modeling for loss-of-control risks from advanced AI. Before that, she led the technical AI safety program at what is now Coefficient Giving.
This is a video version of a post I wrote. If you want to read the original you can check it out here: https://www.dwarkesh.com/p/openai-huggingface
Had a lot of fun chatting again with my twin brother Dylan Patel.
Ryan Greenblatt is the Chief Scientist at Redwood Research, where he works on technical AI safety research. He's also lead author on the "Alignment faking in Large Language Models", and is currently working on a third party investigation…
Read the essay here.
This is a video recording of a post I wrote last week. If you want to read the original you can check it out here. Thanks to Mercury for sponsoring this video. Mercury’s built-in AI, Command, helps me close my books and saves me a bunch of…
Adam Brown is back! General relativity is said to be the most beautiful idea the human mind has ever produced. Most of us will never get to fully appreciate its elegance by taking the 20-lecture graduate course Adam taught on it at…
Always so much fun to chat with Grant. AI has been making much faster progress in math than in other fields. As a result, mathematics is showing us, very concretely, what AI progress in other fields will look like. Even within mathematics…
Read it here. Thanks to Mercury for sponsoring this essay. Mercury has automated basically my entire bill pay process for my business. I just give contractors a dedicated email address, and when they send an invoice, Mercury automatically…
Read the transcript here. Thanks to Mercury for sponsoring this essay! Mercury just released a new feature called Command, which gives me AI right in my banking platform. And since I use Mercury to run basically my entire business, Command…
Had Ada Palmer back on – this time to talk about Machiavelli, perhaps the most misunderstood thinker of all time. Machiavelli cut his teeth as a high-level diplomat for Florence, a position from which he got to closely observe the most…
Economics of AGI episode w Alex Imas and Phil Trammell. There’s a bunch of important questions about how we deal with AI that only economics can answer. What is the optimal way to tax and redistribute the wealth that will be generated? How…
New blackboard lecture with Reiner Pope: how do chips actually work - starting with basic logic gates, and working up to why GPUs, TPUs, FPGAs, and the human brain each look the way they do. Reiner is CEO of MatX, a new chip startup (full…
Eric Jang walks through how to build AlphaGo from scratch, but with modern AI tools. Sometimes you understand the future better by stepping backward. AlphaGo is still the cleanest worked example of the primitives of intelligence: search…
David Reich is back. He and collaborator Ali Akbari just published a paper that overturns a long-standing consensus about human evolution — that natural selection has been dormant in our species since the agricultural revolution. By…
Did a very different format with Reiner Pope - a blackboard lecture where he walks through how frontier LLMs are trained and served. It’s shocking how much you can deduce about what the labs are doing from a handful of equations, public…
I asked Jensen about TPU competition, Nvidia’s lock on the ever more bottlenecked supply chain needed to make advanced chips, whether we should be selling AI chips to China, why Nvidia doesn’t just become a hyperscaler, how it makes its…
Really enjoyed chatting with Michael Nielsen about how we recognize scientific progress. It's especially relevant for closing the RL verification loop for scientific discovery. But it's also a surprisingly mysterious and elusive question…
We begin the episode with the absolutely ingenious and surprising way in which Kepler discovered the laws of planetary motion. People sometimes say that AI will make especially fast progress at scientific discovery because of tight…
Dylan Patel, founder of SemiAnalysis, provides a deep dive into the 3 big bottlenecks to scaling AI compute: logic, memory, and power. And walks through the economics of labs, hyperscalers, foundries, and fab equipment manufacturers.…
Read the full essay here: https://www.dwarkesh.com/p/dow-anthropic
Renaissance history is so much wilder and weirder than you would have expected. Very fun chatting with Ada Palmer (historian, novelist, and composer based at the University of Chicago). Some especially fascinating things I learned from the…
Dario Amodei thinks we are just a few years away from AGI — or as he puts it, from having “a country of geniuses in a data center”. In this episode, we discuss what to make of the scaling hypothesis in the current RL regime, why…
In this episode, John and I got to do a real deep-dive with Elon. We discuss the economics of orbital data centers, the difficulties of scaling power on Earth, what it would take to manufacture humanoids at high-volume in America, xAI’s…
Read the essay here.
This is the final episode of the Sarah Paine lecture series, and it’s probably my favorite one. Sarah gives a “tour of the arguments” on what ultimately led to the Soviet Union’s collapse, diving into the role of the US, the Sino-Soviet…
Ilya & I discuss SSI’s strategy, the problems with pre-training, how to improve the generalization of AI models, and how to ensure AGI goes well. Watch on YouTube; read the transcript.
As part of this interview, Satya Nadella gave Dylan Patel (founder of SemiAnalysis) and me an exclusive first-look at their brand-new Fairwater 2 datacenter. Microsoft is building multiple Fairwaters, each of which has hundreds of…
In this lecture, military historian Sarah Paine explains how Russia—and specifically Stalin—completely derailed China’s rise, slowing them down for over a century. This lecture was particularly interesting to me because, in my opinion, the…
The Andrej Karpathy episode. During this interview, Andrej explains why reinforcement learning is terrible (but everything else is much worse), why AGI will just blend into the previous ~2.5 centuries of 2% GDP growth, why self driving…
Nick Lane has some pretty wild ideas about the evolution of life. He thinks early life was continuous with the spontaneous chemistry of undersea hydrothermal vents. Nick’s story may be wrong, but I find it remarkable that with just that…
I have a much better understanding of Sutton’s perspective now. I wanted to reflect on it a bit.
Richard Sutton is the father of reinforcement learning, winner of the 2024 Turing Award, and author of The Bitter Lesson. And he thinks LLMs are a dead end. After interviewing him, my steel man of Richard’s position is this: LLMs aren’t…
Sergey Levine, one of the world’s top robotics researchers and co-founder of Physical Intelligence, thinks we’re on the cusp of a “self-improvement flywheel” for general-purpose robots. His median estimate for when robots will be able to…
In this lecture, military historian Sarah Paine explains how Britain used sea control, peripheral campaigns, and alliances to defeat Nazi Germany during WWII. She then applies this framework to today, arguing that Russia and China are…
Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting…
How will we feed the 100s of GWs of extra energy demand that AI will create over the coming decade? On this episode, Casey Handmer (Caltech PhD, former NASA JPL, founder & CEO of Terraform Industries) walks me through how we can pull it…
A deep dive with Lewis Bollard, who leads Open Philanthropy’s strategy for Farmed Animal Welfare, on the surprising economics of the meat industry. Why is factory farming so efficient? How can we make the lives of the 23+ billion animals…
After my last lecture series with Sarah Paine ended, I still had so many questions. I knew we’d only scratched the surface of Sarah’s scholarship, so I immediately invited her back for another series: she graciously agreed, and we’ll be…
The Stephen Kotkin episode. Kotkin is arguably the world’s foremost expert on Joseph Stalin and has written a massive 2-volume biography on him (with a 3rd volume in the works). No other individual had more of a profound impact on the 20th…
I’ve had a lot of discussions on my podcast where we haggle out timelines to AGI. Some guests think it’s 20 years away - others 2 years. Here’s an audio version of where my thoughts stand as of June 2025. If you want to read the original…
George Church is the godfather of modern synthetic biology and has been involved with basically every major biotech breakthrough in the last few decades. Professor Church thinks that these improvements (e.g., orders of magnitude decrease…
Arthur Kroeber is a leading researcher on Chinese tech and macro, a founding partner at Gavekal Dragonomics, and author of "China's Economy: What Everyone Needs to Know." It's the most useful, detailed resource I've found of how China…
Ken Rogoff is the former chief economist of the IMF, a professor of Economics at Harvard, and author of the newly released Our Dollar, Your Problem and This Time is Different. On this episode, Ken predicts that, within the next decade, the…
On this episode, I chat with Victor Shih about all things China. We discuss China’s massive local debt crisis, the CCP’s views on AI, what happens after Xi, and more. Victor Shih is an expert on the Chinese political system, as well as…
New episode with my good friends Sholto Douglas & Trenton Bricken. Sholto focuses on scaling RL and Trenton researches mechanistic interpretability, both at Anthropic. We talk through what’s changed in the last year of AI research; the new…
Based on my essay about AI firms. Huge thanks to Petr and his team for bringing this to life! Watch on YouTube. Thanks to Google for sponsoring. We used their Veo 2 model to make this entire video—it generated everything from the…
800 years before the Black Death, the very same bacteria ravaged Rome, killing 60%+ of the population in many areas. Also, back-to-back volcanic eruptions caused a mini Ice Age, leaving Rome devastated by famine and disease. I chatted with…
Ege Erdil and Tamay Besiroglu have 2045+ timelines, think the whole "alignment" framing is wrong, don't think an intelligence explosion is plausible, but are convinced we'll see explosive economic growth (economy literally doubling every…
Scott and Daniel break down every month from now until the 2027 intelligence explosion. Scott Alexander is author of the highly influential blogs Slate Star Codex and Astral Codex Ten. Daniel Kokotajlo resigned from OpenAI in 2024…
I recorded an AMA! I had a blast chatting with my friends Trenton Bricken and Sholto Douglas. We discussed my new book, career advice given AGI, how I pick guests, how I research for the show, and some other nonsense. My book, “The Scaling…
Humans have not succeeded because of our raw intelligence. Marooned European explorers regularly starved to death in areas where foragers thrived for 1000s of years. I’ve always found this cultural evolution deeply mysterious. How do you…
I’m so excited with how this visualization of Notes on China turned out. Petr, thank you for such beautiful watercolor artwork. More to come! Watch on YouTube.
Satya Nadella on: Why he doesn’t believe in AGI but does believe in 10% economic growth; Microsoft’s new topological qubit breakthrough and gaming world models; Whether Office commoditizes LLMs or the other way around. Watch on Youtube…
This week I welcome on the show two of the most important technologists ever, in any field. Jeff Dean is Google's Chief Scientist, and through 25 years at the company, has worked on basically the most transformative systems in modern…
Third and final episode in the Paine trilogy! Chinese history is full of warlords constantly challenging the capital. How could Mao not only stay in power for decades, but not even face any insurgency? And how did Mao go from military…
This is the second episode in the trilogy of a lectures by Professor Sarah Paine of the Naval War College. In this second episode, Prof Paine dissects the ideas and economics behind Japanese imperialism before and during WWII. We get into…
I’m thrilled to launch a new trilogy of double episodes: a lecture series by Professor Sarah Paine of the Naval War College, each followed by a deep Q&A. In this first episode, Prof Paine talks about key decisions by Khrushchev, Mao…
I interviewed Tyler Cowen at the Progress Conference 2024. As always, I had a blast. This is my fourth interview with him – and yet I’m always hearing new stuff. We talked about why he thinks AI won't drive explosive economic growth, the…
