The Great Peptide Debate with Martin Shkreli & Max Marchione
About this episode
From the show’s notesThis is our full interview with Martin Shkreli and Max Marchione, recorded live on TBPN.
We discuss the sharp divide between biotech orthodoxy and the rising peptide movement, unpack the fight over whether compounds like BPC-157 are dangerous gray-market hype or promising under-researched tools with real-world patient impact, and debate whether the FDA should hold the line on traditional evidence standards or adapt to a world where off-label experimentation, compounding, and anecdotal outcomes are already forcing the issue.
Read the show’s notes in full
TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays from 11–2 PT on X and YouTube, with full episodes posted to podcast platforms immediately after.
Described by The New York Times as “Silicon Valley’s newest obsession,” TBPN has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.
Sign up for TBPN’s daily newsletter at TBPN.com
TBPN.com is made possible by:
Ramp - ramp.com
AppLovin -
axon.ai
Cisco -
cisco.com
Cognition -
cognition.ai
Console -
console.com
CrowdStrike -
ElevenLabs -
Figma -
Fin -
Gemini -
Graphite -
Gusto -
Kalshi -
Labelbox -
Lambda -
Linear -
MongoDB -
NYSE -
Okta -
Phantom -
Plaid -
Public -
Railway -
Ramp -
Restream -
Sentry -
Shopify -
Turbopuffer -
Vanta -
Vibe -
shopify.com
