Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founders should be more ambitious than ever, and what two decades of Silicon Valley booms, busts, and missed opportunities have taught Garry about building what's next.

Garry reflects on turning down an early opportunity to join Palantir, why chasing what's "hot" is often the wrong strategy, and why the best ideas tend to begin with people pursuing strange, earnest obsessions outside the mainstream. They also explore how AI changes the economics of company building, why traditional SaaS may be losing its advantage, and how tiny teams equipped with hundreds of agents can build businesses at a scale that once required entire organizations.