# Isomorphic Labs — The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold

- Company: Isomorphic Labs (isomorphiclabs.com)
- Announced: 2026-02-10
- Category: new-model
- Coverage: not counted
- Announcement: yes
- Group: models
- Source: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier
- Record: https://forck.live/items/19144-the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier-beyond-alphafold
- Subject: Drug Design Engine / AlphaFold
- Models affected: AlphaFold 3, Boltz-2, IsoDDE

Isomorphic Labs introduced the Isomorphic Labs Drug Design Engine (IsoDDE), a unified computational drug-design system that demonstrates improved predictive accuracy over AlphaFold 3. On a protein-ligand structure prediction benchmark, IsoDDE more than doubles AlphaFold 3's accuracy on the most difficult systems. It also outperforms AlphaFold 3 by 2.3x and Boltz-2 by 19.8x on a challenging antibody-antigen test set, and surpasses all deep-learning methods on three binding affinity prediction benchmarks.

## Evidence

Verbatim from https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier:

> On the 'Runs N' Poses' benchmark ( Škrinjar et al. 2025 ) - designed specifically to test generalisation to novel pockets and ligands - IsoDDE more than doubles the accuracy of AlphaFold 3 on the most difficult systems.

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